6515--NITRIC OXIDE Notice of Intent to Sole Source

Page 2 of 2 NOTICE OF INTENT TO SOLE SOURCE REQUIREMENT The Department of Veterans Affairs, Ralph H Johnson VAMC, NCO 7 Contracting Activity intends to negotiate a sole source contract under Simplified Acquisition Procedures and the authority of FAR 13.106-1(b)(1)(i) Only one source reasonably available for the following items listed below. The associated NAICS code for this is 325412. The vendor will be INO Therapeutics LLC 1425 US Route 206 Bedminster, NJ 07921-2653. DESCRIPTION OF REQUIREMENTS: Nitric Oxide (NO), not to be confused with the anesthetic nitrous oxide, is a gas molecule with selective vasodilation properties. NO is the active metabolite of a number of other vasodilators, including sodium nitroprusside and nitroglycerin. It is also produced in all human organ systems, including the nasopharynx and lungs. In high concentration, NO is profoundly toxic and causes disease identical to Acute Respiratory Distress Syndrome CARDS). In the presence of oxygen, NO is broken down to form nitrogen dioxide (NO2). In the blood NO interacts with hemoglobin. The byproduct of this reaction produces increased levels of methemoglobin. Methemoglobin will not carry oxygen, and therefore, its level must be closely monitored during NO therapy. Inhaled NO provides selective vasodilatation of the pulmonary arterioles without systemic effect. Vasodilation of the pulmonary arterioles will provide a decrease in pulmonary vascular resistance (PVR) which should improve blood flow to the lung. The INOvent delivery system is an integrated, single unit, designed to administer and monitor inhaled NO. The IN Ovent delivery system connects to the inspiratory limb of the patient breathing circuit. It functions by measuring gas flow in the breathing circuit and injecting the required flow of NO to deliver the concentration set by the user in parts per million. It is designed to deliver a constant concentration of NO, independent of ventilator flow patterns. PERIOD OF PERFORMANCE: October 1,2020- Sept. 30, 2021. It is the Government's belief that only the proposed candidate possesses the required capabilities to successfully meet this requirement. It is the Government's intention to solicit and negotiate with only this source. This notice is not a solicitation or a request for competitive quotes request for offers. No solicitation package is available. However, interested parties may identify their interest and capability to respond to this requirement no later than Sept. 14, 2020 at 9:00 a.m. EST. Any response to this notice must show clear and convincing evidence that competition would be advantageous to the Government. A determination by the Government not to compete this proposed contract based on responses to this notice is solely within the discretion of the Government. All inquiries and documentation must be submitted by email to Lesley Kitchen, Contract Specialist @ [email protected]