NOTICE OF INTENT TO AWARD A SOLE SOURCE PURCHASE ORDER Annual license fee and maintenance for Leadscope Hosted and related datasets. Title of Procurement: License and Maintenance for Leadscope Hosted and related datasets. In accordance with FAR 13.106-1(b)(1), the U.S. Environmental Protection Agency (EPA), Office of Research and Development (ORD), intends to award a sole source purchase order for License and Maintenance for Leadscope Hosted and related datasets to be used in support of ORD¿s National Center for Toxicology (NCCT) Toxcast program. The contract will have a base period of twelve months and two-twelve month option periods each for a total potential contract period of performance of thirty-six months. NCCT has an innovative program which includes the generation of high-throughput screening data for thousands of chemicals, and the development and application of Quantitative Structural Activity Relationship (Q)SAR models for the prediction of relevant toxicities. Leadscope Hosted is a software tool that NCCT has maintained since 2005, that is accessible throughout EPA, and that is in wide use by other Regulatory Agencies worldwide. The software is a unique cheminformatics platform that uses a proprietary set of 27,000 hierarchical, organic structural fragments to probe and extract new chemical insights from user-provided activity data sets. The database ontology was developed in collaboration with researchers at the US EPA and the US Food and Drug Administration (FDA). Leadscope Hosted also provides user access to formalized US FDA animal toxicity databases that are not otherwise publicly available. Additionally, Leadscope has also disseminated the ToxCast and DSSTox libraries to all users as part of their platform. This has expanded the user base of researchers able to interrogate and analyze the data generated within the ToxCast and Tox21 program in a chemical-centric, systematic way, and will be used to magnify the value and broaden the impact of these datasets moving forward. NO REQUEST FOR QUOTE (RFQ) IS AVAILABLE. Notwithstanding, any firm that believes it is capable of meeting EPA's requirement as stated herein may submit a capability statement by the response date indicated. Timely responses will be considered. Responses to this posting must be in writing and provide clear and convincing evidence that competition would be advantageous to the Government. A determination not to compete the proposed purchase order based upon the responses to this notice is solely within the discretion of the Government. All questions should be directed to Jacqueline Sayles via the e-mail link below; telephone calls will not be accepted. The point of contact for this requirement is Jacqueline Sayles, Contract Specialist, at
[email protected]. Responses due 9/12/2015.