TECHNOLOGY TRANSFER OPPORTUNITY –- Aligned and electrospun piezoelectric polymer fiber assembly and scaffold: LAR-17789-1/-2

NASA Langley Research Center in Hampton, VA solicits inquiries from companies interested in obtaining license rights to commercialize, manufacture and market the following technology. License rights may be issued on an exclusive or nonexclusive basis and may include specific fields of use. NASA provides no funding in conjunction with these potential licenses. THE TECHNOLOGY: Scientists at NASA Langley Research Center have developed a scaffold assembly and related methods of manufacturing and/or using the scaffold for stem cell culture and tissue engineering which at least partially mimic a native biological environment by providing biochemical, topographical, mechanical and electrical cues by using an electroactive material. The assembly includes at least one layer of substantially aligned, electrospun polymer fiber having an operative connection for individual voltage application. A method of cell tissue engineering and/or stem cell differentiation uses the assembly seeded with a sample of cells suspended in cell culture media, incubates and applies voltage to one or more layers, and thus produces cells and/or a tissue construct. In another aspect, the invention provides a method of manufacturing the assembly including the steps of providing a first pre-electroded substrate surface; electrospinning a first substantially aligned polymer fiber layer onto the first surface; providing a second pre-electroded substrate surface; electrospinning a second substantially aligned polymer fiber layer onto the second surface; and, retaining together the layered surfaces with a clamp and/or an adhesive compound. NASA is seeking to license this technology commercially in the United States. US Patent 9,005,604. To express interest in this opportunity, please respond to [email protected] with the title of this Technology Transfer Opportunity as listed in this FBO notice and your preferred contact information. Please also provide how you foresee using the technology along with a brief background of your company. Additionally, please identify any non-US interests/subsidiaries in your company as well. For more information about licensing other NASA-developed technologies, please visit the NASA Technology Transfer Portal at http://technology.nasa.gov/ . These responses are provided to members of NASA Langley’s Office of Strategic Analysis and Business Development (OSACB) for the purpose of promoting public awareness of NASA-developed technology products, and conducting preliminary market research to determine public interest in and potential for future licensing opportunities. If direct licensing interest results from this posting, OSACB will follow the required formal licensing process of posting in the Federal Register. No follow-on procurement is expected to result from responses to this Notice.