Antibacterial Compound Optimization_NOI

THIS IS A NOTICE OF INTENT TO AWARD A SOLE-SOURCE CONTRACT AND IS NOT A REQUEST FOR COMPETITIVE PROPOSALS. The U.S. Army Medical Research Acquisition Activity (USAMRAA) intends to award a sole source basis in accordance FAR 6.302-1 with George Mason University (GMU), Fairfax, VA. as the only responsible source that can provide specialized and optimized antibacterial compounds, in support of the Bacterial Disease Branch (BDB) at Walter Reed Institute of Research (WRAIR) located in Silver Spring MD. This acquisition is being conducted under FAR Part 15. Objectives The contractor shall synthesize proprietary antibacterial compounds (CT-AP1) for delivery to WRAIR. The contractor shall synthesize optimized antibacterial compounds for delivery to WRAIR. Specific Tasks / Requirements The contractor shall synthesize proprietary antibacterial compounds (CT-AP1) for delivery to WRAIR for testing in in vitro assays and x-ray crystallography experiments. The contractor shall perform multiple rounds of synthetic synthesis of novel/optimized antibacterials within 2-4 months. The contractor shall synthesize the antibacterial compounds, using structural data and structure-activity relationship data employing their knowledge of chemistry, organic chemistry, medicinal chemistry, and associated laboratory techniques and skills. The contractor shall deliver the optimized synthesized compounds to WRAIR within 1-4 weeks after receiving data from WRAIR. The contractor shall provide a monthly progress report including data and results on relevant tasks performed WRAIR will conduct assay tests including enzyme inhibition, biofilm inhibition and minimum inhibitory concentration (MIC) assays. Assay data will be sent back to contractor and process will repeat until MIC of 1µg/mL is achieved. All compounds shall be shipped to WRAIR with a certificate of analysis indicating at least 95% purity and at least 10mg quantities within 1-4 weeks after receiving data from WRAIR.