Description
17. This is a combined synopsis/notice of intent for commercial items prepared in accordance with the format in Subpart 12.6, as supplemented with additional information includedin this notice. This announcement constitutes the only solicitation; quotes are not being re-quested and a written solicitation will not be issued. This requirement is being issued as a Notice of Intent under NOI4074. This solicitation document and incorporated provisions and clauses are those in effect through Federal Acquisition Circular FAC 01-24. This acquisition will be processed under Simplified Acquisition Procedures (SAP) and is a small business set-aside. The North American Industry Classification System (NAICS) code for this acquisition is 112930 and the Small Business Size Standard $0.75M. The National Institute of Allergy and Infectious Diseases (NIAID) intends to procure Two (2) Male fpr-rs2 kockout mice and Two (2) Female fpr-rs2 knockout mice. These Knockout mice will be procured from Deltagen, Inc. These mice are required to study the role of the receptor gene fpr-rs2 (FPR-L1) in inflammation and Alzheimer’s Disease. This is a continuous study of chemotactic and chemokine receptors and the role they play in human disease. During our studies we discovered that a particular receptor (FPR-L1 in humans and fpr-rs2 in mice) were receptors for amyloid-B. This discovery has suggested that the receptor is involved in Alzheimer’s Disease. The NIH has been working to develop a fpr-rs2 gene deleted mouse to ascertain the role this receptor plays in the disease process. Deltagen, Inc. of San Carlos, California has developed a mouse with its fpr-rs2 gene deleted. Deltagen, Inc. is the only company that has developed the fpr-rs2 knockout mouse. The fpr-rs2 knockout mouse will be used in studies of 1) proinflammatory responses and the expression of cytokines and chemokines; 2) the role of fpr-rs2 in affecting susceptibility to infectious diseases; and 3) the role of fpr-rs2 in the pathogenesis of disease including Alzheimer’s disease. If the knockout mice are dead upon delivery or die within thirty (30) days of delivery through no fault of NIAID, Deltagen will replace any dead mice, if replacement mice are available. If replacement mice are not available, NIAID shall have no obligation to pay the fee. The vendor must have a PHS Approved Animal Welfare Assurance. Delivery is three months after receipt of the purchase order. These mice must be quarantine 8-10 weeks at the Rockville Facility. The FOB Point shall be Destination, Rockville, Maryland, 20852. The government will award a firm fixed price purchase order to the responsible contractor. FAR 52.212-1 Instructions to Offerors – Commercial Items; Offerors must include with their offer a completed copy of the Provision FAR 52.212.3 Offeror Representations and Certifications – Commercial Items; FAR 2.212-3, Offeror Representations and Certification – Commercial Items; FAR 52.212.4 Contract Terms and Conditions of Commercial Items; FAR 52.212-5 Contract Terms and Conditions Required to Implement Statutes of Executive Orders Commercial Items. (B)(1) By submission of an offer, the offeror acknowledges the requirement that a prospective awardee shall be registered in the CCR database prior to award, during performance, and through final payment of any contract, basic agreement, basic ordering agreement, or blanket purchasing agreement resulting from this solicitation. CCR website at http://www.ccr.dlis.dlaimil; delivery must be no later than September 9, 2004. Offers must be submitted no later than 5:00 P.M. Eastern Daylight Time (EDT), July 29, 2004, to Linda Taylor. Copies of the aforementioned clauses are available upon request by telephone to Linda Taylor, 301-402-2282. For delivery through the Postal Service, the address is AMOB/NIAID/NIH, 10401 Fernwood Drive, Suite 2NE70, Room/2NE46, MSC/4812, Bethesda, Maryland 20817-4812. Electronic Submission will not be accepted. Request for information concerning this requirement is to be addressed to Linda Taylor at the address mentioned. Collect calls will not be accepted. All responsible sources may submit an offer that will be considered by this agency.