Quantify the expression of metabolizing enzymes and transporter proteins in lung, eye and skin tissue in relevant animal models and humans (U01) Clinical Trial Not Allowed

The purpose of this funding opportunity is to systematically quantify the protein levels of potential metabolizing enzymes and transporters in rabbit and human eye tissue, human lung tissue, and human skin tissue using most advanced techniques, where individual proposals will select one research area (i.e., ophthalmic, dermal, or pulmonary). Subsequently, the experimental data collected from this study will be implemented into existing modeling platforms to allow for virtual bioequivalence (BE) assessments locally and systemically for the parent and pharmacologically active metabolite.