Expanding the opioids system modeling efforts to more comprehensively address fentanyl, stimulants use, polysubstance use and associated outcomes.(U01) Clinical Trials Not Allowed

The purpose of this funding opportunity is to expand on the FDA's modeling efforts to more comprehensively address fentanyl, stimulants and polysubstance use and their interactive effects on opioids use, misuse, use disorder, addiction treatment, and associated outcomes. The primary purpose of this project is to capture the dynamics of and interactions between stimulant or polysubstance use and opioid overdose deaths, as an important emerging aspect of the opioids crisis. The research should also seek to quantify how polysubstance use and synthetic opioids may influence the effects of harm reduction approaches and other potential overdose-prevention strategies. A secondary purpose of the research is to identify and implement feasible approaches for incorporating mental health into part of FDA's modeling effort.