Bruker Biotype 1

CDC is requesting to purchase the Mass Spectrometry Technology. Bruker MALDI Sirius CA system is the only FDA approved benchtop mass spectrometry system with a small footprint requiring less than 3 feet of counter space and a 110 V electrical outlet to identify the organisms we require (clinically relevant gram-negative and positive bacteria). Due to its 110V electrical supply, the instrument generates minimal heat which makes it suitable for the small procedure room identified for its use. The available room serves several purposes and cannot be reconfigured to accommodate a large piece of equipment. Due to these space constraints, the Bruker MALDI Biotyper sirius CA benchtop instrument is the only mass spectrometry instrument that will meet the branch’s needs. The comparable mass spectrometry instruments offered by BioMerieux (Vitek MS) and Shimadsu (Axima MS) are 200-230 V floor model instruments approximately the size of a vending machine and cannot be accommodated without loss of valuable functionality in the available room. The Bruker MALDI sirius CA system is also the only system that can generate spectra compatible with extensive databases developed in-house by other groups at CDC (MicrobeNet) to leverage these valuable resources. In addition, the system has a unique, proprietary software module that can extract additional subtyping information from spectrograms for Listeria spp., an important foodborne pathogen the branch has responsibility for, to rapidly provide information to help guide outbreak investigations.