In vitro-In vivo Correlations of Parenteral Microsphere Drug Products

The purpose of this study is to investigate in vitro-in vivo correlations of parenteral microspheres. The encapsulated agent may be a small molecule or peptide, and the dosage form should be an injectable. An in vitro dissolution test which correlates with in vivo absorption should be investigated. In vivo studies should be conducted in a suitable animal model.The results from this project will help to understand the release mechanisms of microspheres and how in vitro studies could be used to predict in vivo bioavailability.